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Symbol
Name
ID

Shank2
SH3 and multiple ankyrin repeat domains 2
MGI:2671987

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	EEG abnormality	Abnormal nonverbal communicative behavior	Delayed speech and language development	Lack of spontaneous play	Impaired ability to form peer relationships	Autism	Inflexible adherence to routines	Motor stereotypy	Restrictive behavior	Intellectual disability	Seizure
Disease(s) Associated with SHANK2
autistic disorder

Mouse Phenotypes		nervous system phenotype	abnormal cerebellar molecular layer	abnormal dendritic spine morphology	abnormal excitatory synapse morphology	abnormal nervous system physiology	abnormal excitatory postsynaptic potential	enhanced long-term potentiation	reduced long-term potentiation	abnormal miniature excitatory postsynaptic currents	reduced long-term depression
Availability	Mouse Genotype	nervous system phenotype	abnormal cerebellar molecular layer	abnormal dendritic spine morphology	abnormal excitatory synapse morphology	abnormal nervous system physiology	abnormal excitatory postsynaptic potential	enhanced long-term potentiation	reduced long-term potentiation	abnormal miniature excitatory postsynaptic currents	reduced long-term depression
	Shank2^tm1.1Tmb/Shank2^tm1.1Tmb
	Shank2^tm1Mgle/Shank2^tm1Mgle	*
	Shank2^tm1.1Tmb/Shank2⁺
	Shank2^tm1.1Bcgen/Shank2^tm1.1Bcgen Tg(Pcp2-cre)2Mpin/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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